Object.defineProperties() allows defining multiple properties in a single atomic operation: 1) It's more concise when defining several properties at once, 2) It's syntactically cleaner for related properties, 3) All properties are defined in a single operation, which can be more efficient, 4) It supports the same full range of property descriptors as Object.defineProperty(), 5) It can define both data properties and accessor properties together, 6) It's particularly useful when creating objects with interdependent properties, 7) It improves code readability when dealing with complex object initialization.