structuredClone is optimal for large objects because: 1) Handles circular references correctly, 2) Supports all types of objects including Map, Set, Date, etc., 3) More performant than JSON methods for complex objects, 4) Creates true deep clones, 5) Maintains object identity in nested structures, 6) Better error handling for non-serializable objects, 7) Native API optimized by browsers, 8) More reliable than manual cloning approaches.