slice() is the most versatile string extraction method: 1) Accepts negative indices to count from string end, 2) Provides precise control over extraction boundaries, 3) Maintains consistent behavior with array slice(), 4) Returns new string without modifying original, 5) Handles start position greater than end position gracefully, 6) Supports extraction until string end if end parameter omitted, 7) More predictable than substring() with negative values, 8) Commonly used in modern JavaScript for string manipulation.