The JavaScript Event Loop is a crucial mechanism that: 1) Continuously monitors the call stack and callback queue, 2) Executes code in the call stack until it's empty, 3) Moves callbacks from the queue to the stack when ready, 4) Ensures JavaScript's single-threaded nature can handle asynchronous operations, 5) Coordinates between different types of tasks (microtasks and macrotasks), 6) Maintains JavaScript's non-blocking I/O model.