Conditional module loading differences: 1) CommonJS allows synchronous conditional requires, 2) ES Modules require dynamic import() for conditional loading, which is always asynchronous, 3) CommonJS provides simpler syntax for conditional loading, 4) ES Modules' approach returns a Promise that must be handled, 5) CommonJS's approach can impact static analysis and bundling, 6) ES Modules' approach better supports code splitting, 7) These differences affect how applications can implement dynamic loading strategies.